Process control and optimization


Process Visualisation Software LPC plus


LPC plus is a process visualisation software developed by MARTIN CHRIST, which covers all requirements with regard to process data recording, process visualisation and equipment operation for freeze dryers in compliance with international guidelines and regulations (GxP, GAMPx, 21 CFR Part11).

Performance characteristics

+ Detailed mimic screen of the freeze drying unit with animated visual objects and configurable actual / set values displays
+ Process events (Audit-Trail)
+ Process graphics : configurable temperature & vacuum scales, zoom facility
+ Administration / modification of user programs / recipes
+ User Administration : unrestricted number of users / 6 user levels / unrestricted definition of user-identification- and password-spelling / user-configurable assigment of all LPC plus operating functions to one of the available user levels / configurable time interval for user password validity / enable-disable LPC plus users / user-disable for non-valid logon-attempts (configurable counter)
+ Process documentation ("Historical" Processdata) and Processdata Backup
+ Administration of batch related data
+ Administration / modification of set values for "manual" mode
+ Administration / modification of set values and parameter-configuration of "accompanying" processes :
Sterilisation In Place (SIP)
Clean in Place (CIP)
Filter Integrity Test (FIT)
+ Engineering mode
+ Indication of operating hours and maintenance information
+ Communication
Remote maintenance
Transmission of alarm messages via SMS
Integration into Local Area Networks
+ LPC plus is designed for keyboard/mouse and/or Touch Screen operation in relation to the appearance / size and placement of the control elements.
+ Online Help system


CHRIST micro balance for online determination of residual moisture inside the product


With the unique CHRIST micro balance you can monitor the progress in the drying process without any influences to the process. The transition from sublimation to desorption can be determined as well as the drying speed using different p,T-profiles. Thus the drying cycles can be optimized. You obtain stable products without the need of needlessley long drying cycles. Limitations: The high accuracy of measurement is limited to -40°C ... +40°C and the balance can't be used in sterile processes.

Figure 3:

Determination of end of main drying by using the micro balance  

Figure 4:

Effect of shelf temperature and vacuum to the sublimation rate measured

with the micro balance